Cinnamic acids and derivatives
Medchemexpress LLC (2E,4E)-Hepta-2,4-dienal | 4313-03-5 | 90.6% | 110.16 | 5 G
(2E,4E)-Hepta-2,4-dienal is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
- Can be used as a biological material or organic compound for life science related research
- For research use only
- Not sold to patients
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
![Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402443-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, showing at least 500-fold higher selectivity for ErbB2 over EGFR. This compound exhibits anticancer activity.
- Significantly decreases cell proliferation in various cell lines
- Induces a dose-dependent increase in apoptosis
- Reduces tumor sizes in animal models
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.58% | 339.39 | 100 MG
Curcumin 5-8 is a potent, orally active curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity, and has been shown to ameliorate nonalcoholic fatty liver disease in mice.
- Decreases PA-induced SREBP1 expression and increases Bcl2/BAX expression in AML12 cells.
- Exhibits cytotoxic activity against B16, HUVEC, SiHa, U-87MG ATCC, and Vero cell lines.
- Ameliorates insulin resistance and hepatic steatosis in HFD-induced obese mice.
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 25 MG
Tyrphostin A1 (AG9) is a compound that inhibits CD40L-stimulated IL-12 production and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus, reducing IL-12 p40 gene activation. In vivo, it decreases the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE).
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Inhibits antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of the IL-12 p40 gene
- Decreases generation of myelin basic protein (MBP) specific encephalitogenic T cells
- Attenuates experimental allergic encephalomyelitis (EAE)
- Differentiates TK-mediated effects from non-specific effects due to weak TK inhibition (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | 97.0% | 280.36 g/mol | C19H20O2 | 5 MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one is a diarylheptanoid small-molecule for laboratory research and analytical applications. The compound is supplied as a solid with molecular formula C19H20O2, molecular weight 280.36 g/mol, and an analytical purity of 97.0% (NMR). Store protected from light at low temperatures; consult the certificate of analysis for batch-specific handling and stability information.
- Solid, white to off-white appearance.
- Molecular formula C19H20O2.
- Molecular weight 280.36 g/mol.
- Analytical purity 97.0% (NMR).
- Storage: keep container tightly sealed, protect from light; recommended -20°C for solid, in solvent -80°C for 6 months or -20°C for 1 month.
- Intended for research and analytical use only; not for human therapeutic use.
Medchemexpress LLC (2E,4E)-Hepta-2,4-dienal | 4313-03-5 | 90.6% | 110.16 | 10 G
(2E,4E)-Hepta-2,4-dienal is a naturally occurring organic compound belonging to the group of aldehydes. It is an unsaturated aldehyde with two conjugated double bonds, giving it unique chemical and physical properties. It is commonly found in various plant sources, especially in spices such as parsley and coriander. It can be used as a biological material or organic compound for life science related research.
- Biochemical reagent for life science related research
- Naturally occurring organic compound
- Found in plant sources like parsley and coriander
- Used as a flavoring agent and food additive
- Also used in the fragrance industry
![Medchemexpress LLC 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile | 118409-58-8 | MFCD00133900 | 99.0% | 202.17 g/mol | C10H6N2O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247987.png-250.jpg)
Medchemexpress LLC 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile | 118409-58-8 | MFCD00133900 | 99.0% | 202.17 g/mol | C10H6N2O3 | 5 MG
Tyrphostin 25 (AG82) is a small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that also acts as a GPR35 agonist. It is commonly used in cell signaling and pharmacology research; reported activities include EGFR inhibition (IC50 ≈ 3 μM in A431 cells) and GPR35 activation (EC50 ≈ 5.3 μM).
- Selective EGFR tyrosine kinase inhibition for cell signaling and migration studies.
- GPR35 agonist activity supports investigation of alternative GPCR-mediated pathways.
- High purity (~99.0%) suitable for biochemical and cellular assays.
- Solid, yellow-brown material with molecular weight 202.17 and formula C10H6N2O3.
- Recommended storage: powder at -20°C (stable ~3 years); in solvent store at -80°C for long-term stability.
![eMolecules 176776-60-6 | 2,2'-(1E,1'E)-(TRANS (+/-)-CYCLOHEXANE-1,2- DIYLBIS(AZAN-1-YL-1-YLIDENE)BIS(METHAN-1-YL-1-YLIDENE)DIPHENOL | AstaTech644.816 | C40H44N4O4 | 95.000 | Oc1ccccc1\C=N\[C@@H]1CCCC[C@H]1\N=C\c1ccccc1O.Oc1ccccc1\C=N\[C@H]1CCCC[C@@H]1\N=C\c1ccccc1O | 1g | 112531835](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502171610.JPG-250.jpg)
eMolecules 176776-60-6 | 2,2'-(1E,1'E)-(TRANS (+/-)-CYCLOHEXANE-1,2- DIYLBIS(AZAN-1-YL-1-YLIDENE)BIS(METHAN-1-YL-1-YLIDENE)DIPHENOL | AstaTech644.816 | C40H44N4O4 | 95.000 | Oc1ccccc1\C=N\[C@@H]1CCCC[C@H]1\N=C\c1ccccc1O.Oc1ccccc1\C=N\[C@H]1CCCC[C@@H]1\N=C\c1ccccc1O | 1g | 112531835
2,2'-(1E,1'E)-(TRANS (+/-)-CYCLOHEXANE-1,2- DIYLBIS(AZAN-1-YL-1-YLIDENE)BIS(METHAN-1-YL-1-YLIDENE)DIPHENOL | AstaTech | 176776-60-6644.816 | C40H44N4O4 | 95.000 | Oc1ccccc1\C=N\[C@@H]1CCCC[C@H]1\N=C\c1ccccc1O.Oc1ccccc1\C=N\[C@H]1CCCC[C@@H]1\N=C\c1ccccc1O | 1g | 112531835
Medchemexpress LLC (E,E)-Bisdemethoxycurcumin (Standard) | 33171-05-0 | 98.5% | 308.33 | 1MG
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin, designed for research and analytical applications. This curcumin derivative possesses anti-inflammatory and anticancer activities. It serves as a reference standard for assays and is commonly used in qualitative, quantitative, and methodological research experiments like HPLC, GC, and MS.
- Intended for research and analytical applications
- Possesses anti-inflammatory and anticancer activities
- Analytical standard grade for assays
- Suitable for HPLC, GC, and MS experiments
TARGETMOL CHEMICALS INC TYRPHOSTIN AG 538 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Tyrphostin AG 538 is a chalcone compound an IGF-1 receptor kinase inhibitor (IC₅0 for 400 nM) that is potent cell-permeable reversible and competitive. purity: 99%
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 10MM 1ML
SAR405 R enantiomer is the less active enantiomer of SAR405, a selective inhibitor of PIK3C3/Vps34, supplied for research use. It is offered as a ready-to-use 10 mM solution in DMSO or as a solid, and is used as a reference or control in studies of autophagy, vesicle trafficking, and related signaling pathways.
- Less active enantiomer of a PIK3C3/Vps34 inhibitor.
- High purity (~99.9%) for reliable experimental controls.
- Available as 10 mM solution in DMSO and multiple solid package sizes.
- Soluble in DMSO at 100 mg/mL; ultrasonication may be required.
- Storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
- Intended for research use only, not for clinical applications.
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | >98.0% | 305.29 g/mol | C14H15N3O5 | 5 MG
Entacapone is a research-grade catechol-O-methyltransferase (COMT) inhibitor supplied as a small-scale reagent. It is potent, reversible, peripherally acting, and orally active, and is used in Parkinson's disease research and studies of FTO demethylation.
- Potent, reversible COMT inhibitor.
- Peripherally acting and orally active.
- Suitable for Parkinson's disease research.
- Inhibits FTO demethylation for metabolic research.
- Purity >98.0% (HPLC) reported by suppliers.
- Molecular formula C14H15N3O5; molecular weight 305.29 g/mol.
- Supplied as a small-scale research pack (5 mg).